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Enselin MF 4mg/500mg Tablet is a combination of two antidiabetic medicines: Rosiglitazone and Metformin. Rosiglitazone is a thiazolidinedione which works by increasing the body's sensitivity to insulin. Metformin is a biguanide. It works by lowering sugar production in the liver, delaying sugar absorption from intestines and increasing the body's sensitivity to insulin.