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Drez V Vaginal cream is a combination of two medicines: Clindamycin and Clotrimazole. Clindamycin is an antibiotic which stops bacterial growth in the vaginal tract by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Clotrimazole is an antifungal which stops the growth of fungi by preventing them from making their protective covering. Together, they treat your vaginal infection effectively.